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Hi-Tech has been a pioneer in Berberine research with its Nexrutine® product. Our next-generation Nexrutine® XS Berberine Pharmacokinetic study demonstrates a remarkable improvement in berberine bioavailability (AUC) over 10 times on a molar basis and with observed dose linearity. Our product has extended retention time from 30-45 minutes to over 10 hours!
The uniqueness of Nexrutine® XS Berberine lies in its ability to overcome berberine’s main limitation: poor bioavailability. Traditional raw berberine extracts have extremely low oral bioavailability and bioabsorption profiles. Nexrutine® XS Berberine is a groundbreaking supplement that harnesses the power of berberine to provide a natural and effective solution for blood sugar metabolism support and healthy weight management.
Nexrutine® XS Berberine effectively supports metabolic health, favorably modulating insulin response, improving the blood sugar profile, leveling blood glycemic and insulin levels, optimizing the blood lipid profile, positively affecting body composition, and promoting healthy cholesterol levels.
Hi-Te utilizes our proprietary Cyclosome® structure, a unique sunflower lecithin and cyclodextrin structure that ensures your body can absorb plant extracts effectively. For Nexrutine® XS Berberine, we also incorporate sodium caprate (C10, a medium-chain triglyceride) to promote optimal absorption and gastrointestinal comfort during berberine supplementation.
Take two (2) tablets 2-3 times daily or as directed.
We generally take 2–5 business days for order processing and fulfillment before shipping, with total delivery for US orders typically arriving in about 4–9 business days when combining fulfillment and standard shipping. Express shipping options (1–3 business days) are available for faster delivery.
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Hi-Tech Pharmaceuticals

Product Manager
Medicine Specialist
Fitness Enthusiast
PhD